Are fentanyl and sufentanil the same?
Both fentanyl and sufentanil are formulated with the same concentration (50 μg/ml), but sufentanil is 4.4 times more potent at the ED50when administered intrathecally. An overdose resulting in severe respiratory depression and other side effects could occur if sufentanil were mistaken for fentanyl, but not vice versa .
How long does 50mg of fentanyl last?
After intravenous administration in unpremedicated adult patients, 2 ml fentanyl may be expected to provide sufficient analgesia for 10-20 minutes in surgical procedures involving low pain intensity.
What is the duration of action for fentanyl?
Following intramuscular administration, the onset of action is from seven to eight minutes, and the duration of action is one to two hours. As with longer acting opioid analgesics, the duration of the respiratory depressant effect of fentanyl may be longer than the analgesic effect.
Which is stronger fentanyl or sufentanil?
During titrated, intermediate-term infusions in patients previously treated with opioids for chronic pain, sufentanil is approximately 7.5 times as potent as fentanyl.
Is Alfenta the same as fentanyl?
Alfentanil is a tetrazole derivative of fentanyl with many pharmacologic actions similar to those of fentanyl and sufentanil; however, alfentanil has a quicker onset of action than fentanyl and a shorter duration of action than either fentanyl or sufentanil.
Can you have fentanyl and morphine together?
The present results suggest that the combination of fentanyl with morphine for intravenous patient-controlled analgesia is a useful method, and the double dose of fentanyl in comparison with the equipotent morphine dose is recommended in the early postoperative period.
Why fentanyl is given?
Fentanyl injection is used to relieve severe pain during and after surgery. It is also used with other medicines just before or during an operation to help the anesthetic (numbing medicine) work better. Fentanyl belongs to the group of medicines called narcotic analgesics (pain medicines).
How much more potent is sufentanil to fentanyl?
Which is more potent fentanyl or alfentanil?
Fentanyl is four times more potent than alfentanil.
How much stronger is sufentanil then fentanyl?
Sufentanil, like fentanyl, has no active metabolites. It is 5-10 times more potent than its parent drug fentanyl 5, 19.
What is the difference between sufentanil and fentanyl?
Although sufentanil is typically considered to be 5 to 10 times more potent than fentanyl, it has a shorter half-life than fentanyl—approximately half as long (5). Therefore, we front-loaded sufentanil at approximately one third the dose of the fentanyl to compensate for the shorter half-life.
What is the duration of analgesia after sufentanil?
The duration of analgesia was higher in patients who received sufentanil than those who received fentanyl (113 ± 45 vs. 103 ± 22 minutes (P = 0.629)). The pain score in the Fentanyl group was significantly lower at 5, 10, and 15 minutes after spinal analgesia (P < 0.05).
Does remifentanil reduce extubation time for patients with fentanyl?
In a small study of 27 patients (another 9 patients were excluded for death or prolonged hospital stay), the Remifentanil group had shorter (by an average of 2.5 hours) times to extubation and shorter (6.6 ± 0.26 vs 8.4 ± 0.5 days, mean ± sem, P = 0.015) hospital stays compared with patients receiving fentanyl (10).
How many milligrams of alfentanil does it take to wake you up?
Mean total doses of alfentanil, fentanyl and sufentanil were 443, 45 and 4.4 µg kg –1, respectively. Time to awakening did not differ significantly. In patients receiving fentanyl, the trachea was extubated on average 2 h later than in those receiving sufentanil and 3 h later than in those receiving alfentanil ( P <0.05).