What is CD57 marker for?
CD57 is a very useful marker of NK cell maturation, identifying cells with potent cytotoxic potential but decreased sensitivity to cytokines and reduced replicative potential.
What cells express CD57?
CD57 is a Marker of NK Cell Differentiation CD57 was subsequently identified on CD8+ T cells (5–7) as well as cells of neural crest origin (1, 8–13). Indeed, it was the neuroscience community that ultimately defined CD57 as a terminally sulfated carbohydrate epitope (glucuronic acid 3-sulfate) (14–16).
What is CD8 CD57?
Background The repetitive antigen stimulation during chronic infection often leads to the accumulation of CD8+CD57+ T cells. These cells express high levels of interferon-γ, granzyme B and perforin with elevated cytolytic effect, and are considered as the most potent cells for combating chronical viral infection.
What does it mean to have a low CD57 count?
Test interpretation: Low CD-57 occurs in chronic Lyme or when the disease has been active for over 1 year. The count reflects the degree of infection. It is not a diagnostic test but is used as a marker for Lyme being active. >200 is normal. < 20 severe illness.
What is a normal CD57 count?
The standard normal range for the absolute CD57 NK count is 60 to 360 cells per microliter of blood. This wide range was established based upon test results of hundreds of healthy patients.
What does a high CD57 mean?
It is generally believed that the lower the amount of CD57 natural killer cells in the body, the more chronic or progressive Lyme disease is, and the higher the amount, the closer a person is to remission.
What is a low CD57?
Test interpretation: Low CD-57 occurs in chronic Lyme or when the disease has been active for over 1 year. The count reflects the degree of infection. It is not a diagnostic test but is used as a marker for Lyme being active.
What does a high CD57 count mean?
Can Lyme go away on its own?
Can Lyme Disease Go Away on Its Own? It is possible a person with Lyme disease can clear the infection on their own, but it’s better to be treated because complications that can arise are very serious. For most people, the disease and its symptoms do not resolve without treatment.
Why is CD57 low in Lyme?
How long does a CD57 test take?
Turnaround time for the Lyme Disease CD57 HNK1 is typically 1-3 business days. Detection Period: The amount of time it takes for a person’s immune sytem to be affected by Lyme Disease varies. It is recommended that a person consult their doctor to determine if this test is relevant for their situation.
Can you get Lyme disease twice?
Reinfection: You can get Lyme disease again if you are bitten by another infected tick, so protect yourself from tick bites. People treated with antibiotics for early Lyme disease usually recover rapidly and completely.