What does thrombotic thrombocytopenic purpura look like?

Your symptoms may include: Petechiae, which are small, flat red spots under the skin caused by blood leaking from blood vessels. Purpura, which is bleeding in your skin that can cause red, purple, or brownish- yellow spots. Paleness or jaundice (a yellowish color of the skin or whites of the eyes)

What does thrombocytopenia look like on a blood smear?

Peripheral blood smear from a patient with immune thrombocytopenia (ITP) shows a decreased number of platelets, a normal-appearing neutrophil, and normal-appearing erythrocytes.

How is thrombotic thrombocytopenic purpura diagnosed?

Complete blood count (CBC). A CBC measures the number of platelets as well as the number of red blood cells and white blood cells.
Bilirubin test.
Blood smear.
Urine or kidney function tests.
Creatinine test.
Lactate dehydrogenase test.
ADAMTS13 assay.

What are the laboratory findings seen in TTP?

TTP patients usually present with a characteristic set of laboratory findings. This includes a negative direct antiglobulin test (DAT), microangiopathic hemolytic anemia (MAHA), and thrombocytopenia, which are considered major laboratory criterion of TTP.

What are the signs and symptoms of purpura?

Symptoms of purpura

low platelet count, which may lead to increased bleeding after an injury, bleeding gums or nose, or blood in urine or bowel movements.
sore, swollen joints, particularly in the ankles and knees.
gut problems such as nausea, vomiting, diarrhea, or stomach pain.

Is purpura a blood clotting disorder?

Description. Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart.

What does a blood smear show?

A blood smear is a type of blood test. It looks at the appearance, number, and shape of your red and white blood cells and platelets to see whether they are normal. A blood smear can also detect parasites in your blood. It is now more common to have blood analyzed by a computer.

What causes thrombocytopenic purpura?

This disease is caused by an immune reaction against one’s own platelets. It has also been called autoimmune thrombocytopenic purpura. Thrombocytopenia means a decreased number of platelets in the blood. Purpura refers to the purple discoloring of the skin, as with a bruise.

What is the pathophysiology of thrombotic thrombocytopenic purpura?

Abstract. Thrombotic thrombocytopenic purpura (TTP) is a disorder with characteristic von Willebrand factor (VWF)-rich microthrombi affecting the arterioles and capillaries of multiple organs. The disorder frequently leads to early death unless the patients are treated with plasma exchange or infusion.

What is thrombotic thrombocytopenic purpura?

Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.

Which lab tests are used in the workup of thrombocytopenic purpura?

Complete blood count with platelets, peripheral blood smear, direct antiglobulin (Coombs) test, lactate dehydrogenase (LDH), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, haptoglobin Thrombotic thrombocytopenic purpura is suspected in patients with suggestive symptoms, thrombocytopenia, and anemia.

What is included in long-term follow-up of patients with thrombocytopenic purpura (TTP)?

Long-term follow-up of patients with TTP, including medical consultation, standard biology, and ADAMTS13 activity monitoring, is also justified by the relapsing risk of this disease.

How does influenza A cause thrombocytopenic purpura (THP)?

Kosugi N., Tsurutani Y., Isonishi A., Hori Y., Matsumoto M., Fujimura Y. Influenza A infection triggers thrombotic thrombocytopenic purpura by producing the anti-ADAMTS13 IgG inhibitor. Intern. Med. 2010;49:689–693. doi: 10.2169/internalmedicine.49.2957.