What is focal incomplete intestinal metaplasia?
Incomplete or Type II IM means the new cells more closely resemble the cells of your large intestine (colon). This is considered an advanced stage of IM and is more likely to progress to dysplasia. Some scientists also define a Type III based on a slightly different configuration of cells.
What are the stages of intestinal metaplasia?
The development of gastric adenocarcinoma of the intestinal type is thought to progress sequentially through four stages: nonatrophic gastritis, multifocal atrophic gastritis, IM, and dysplasia.
What is the complication of intestinal metaplasia?
Complications from intestinal metaplasia Intestinal metaplasia is believed to be a precancerous lesion that may lead to gastric cancer. If you have intestinal metaplasia, then your risk of getting gastric cancer is increased six times .
Is focal intestinal metaplasia precancerous?
Some doctors consider intestinal metaplasia to be a precancerous condition. Intestinal metaplasia is more common in people who have chronic acid reflux or gastroesophageal reflux disease (GERD). Some doctors think bacteria called H. pylori causes this change in the digestive tract.
Can you drink alcohol with intestinal metaplasia?
We found no association between alcohol drinking status and risk of non-cardia gastric intestinal metaplasia (current drinkers vs. lifelong non-drinkers; adjusted OR, 1.03; 95% CI, 0.63–1.68). Likewise, there was no association with average amount of alcohol consumed over the life-course, even for heavy drinkers.
What does metaplasia mean?
Listen to pronunciation. (meh-tuh-PLAY-zhuh) A change of cells to a form that does not normally occur in the tissue in which it is found.
What is gastric mucosa with intestinal metaplasia?
Gastric intestinal metaplasia (GIM) is an intermediate precancerous gastric lesion in the gastric cancer cascade of chronic gastritis, atrophic gastritis, intestinal metaplasia (IM), dysplasia, and adenocarcinoma [1]. Although the risk of gastric cancer is increased in patients with GIM, the absolute risk is modest.
Does metaplasia lead to dysplasia?
Universally, metaplasia is a precursor to low-grade dysplasia, which can culminate in high-grade dysplasia and carcinoma. Improved clinical screening for and surveillance of metaplasia might lead to better prevention or early detection of dysplasia and cancer.
Is metaplasia reversible or irreversible?
Metaplasia is defined as a potentially reversible change from a fully differentiated cell type to another, which implies adaptation to environmental stimuli, and that embryological commitments can be reversed or erased under certain circumstances.
Is there a cure for intestinal metaplasia?
Gastric intestinal metaplasia (GIM) is precancerous with a worldwide prevalence of 25%. Eradicating Helicobacter pylori prevented about half of gastric cancers; failure to prevent the rest was attributed to GIM. GIM is irreversible and often extensive. There is no treatment.