Can HSP cause brain damage?
Inflammatory changes associated with HSP can also develop in the joints, kidneys, digestive system, and, in rare cases, the brain and spinal cord (central nervous system).
What type of hypersensitivity is Henoch-Schönlein purpura?
Henoch–Schönlein purpura is a small-vessel vasculitis in which complexes of immunoglobulin A (IgA) and complement component 3 (C3) are deposited on arterioles, capillaries, and venules (hence it is a type III hypersensitivity reaction).
What is the pathophysiology of HSP?
The pathophysiology of Henoch-Schönlein purpura is not fully understood; however, IgA plays a significant role. IgA-antibody immune complexes caused by antigenic exposure from an infection or medication deposit in the small vessels (usually capillaries) of the skin, joints, kidneys, and gastrointestinal tract.
Can HSP cause seizures?
Neurological symptoms and signs occur in a significant proportion of cases with HSP. Although headache and behavioural changes are seen in many patients, severe neurological manifestations such as seizures, intracerebral haematoma, hemiplegia, and encephalopathy are rare [2,7–10].
Is Henoch-Schonlein autoimmune?
HSP is an autoimmune disease that is often triggered by an upper respiratory infection. Symptoms include a rash caused by bleeding under the skin, arthritis, belly pain, and kidney disease. Most children recover fully.
Can HSP recur years later?
About one third of children diagnosed with Henoch-Schönlein purpura will develop recurrent symptoms of Henoch-Schönlein purpura, although most recurrent episodes are less severe than the initial episode. However, recurrent episodes of Henoch-Schönlein purpura can last up to a year after the initial diagnosis.
What are the signs and symptoms of Henoch-Schönlein Purpura IGA vasculitis )?
The four main characteristics of Henoch-Schonlein purpura include:
- Rash (purpura). Reddish-purple spots that look like bruises develop on the buttocks, legs and feet.
- Swollen, sore joints (arthritis).
- Digestive tract symptoms.
- Kidney involvement.
Is Henoch-Schönlein autoimmune?
Does HSP cause thrombocytopenia?
Henoch-Schönlein purpura is an acute, systemic, immune complex-mediated, leukocytoclastic vasculitis. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain, and arthritis. Most patients have an antecedent upper respiratory illness.
Is Henoch-Schonlein purpura serious?
The most serious complication of Henoch-Schonlein purpura is kidney damage. This risk is greater in adults than in children. Occasionally the damage is severe enough that dialysis or a kidney transplant is needed.
Does HSP have any long term effects?
Long lasting effects of HSP Any kidney problems usually get better without treatment. But sometimes HSP can be severe and last several months, particularly in adults. There’s also a small chance the kidneys could be permanently damaged (chronic kidney disease). This is why it’s important to have regular check-ups.
How common is central nervous system involvement in Henoch-Schonlein purpura?
Central nervous system (CNS) involvement in Henoch-Schonlein purpura (HSP) is rare but poses diagnostic difficulties. The aim of the study was to establish the frequency of CNS involvement in HSP, to analyze its clinical characteristics and do a literature review.
What is Henoch Schönlein purpura?
Henoch Schönlein Purpura – StatPearls – NCBI Bookshelf Henoch-Schönlein purpura is a vasculitis involving the small vessels of the joints, kidneys, gastrointestinal tract, and skin. Henoch-Schönlein purpura can also involve the central nervous system (CNS) and the lungs; however, these findings are rare.
What is the prognosis of Henoch-Schönlein purpura?
Henoch-Schönlein purpura is typically a self-limited illness that demonstrates an excellent prognosis in patients without renal involvement. The majority of patients fully recover in four weeks.[2] Henoch-Schönlein Purpura recurs in approximately one-third of patients within 4 to 6 months after the initial onset.
What is the treatment for chronic IgA vasculitis (Henoch-Schonlein disease)?
Bech AP, Reichert LJ, Cohen Tervaert JW. Dapsone for the treatment of chronic IgA vasculitis (Henoch-Schonlein). Neth J Med. 2013;71 (4):220–221.