Does Phenergan cause QT prolongation?
In conclusion, promethazine induces significant QTc prolongation but the lack of influence on transmural dispersion of repolarisation makes the risk of its torsadogenic action very low.
Which of following drug causes QT prolongation?
A long QT interval is most frequently seen with class I and class III antiarrhythmic drugs. Other classes of drugs that cause QTc prolongation include antihistamines, antidepressants, antibiotics, antifungal drugs and antipsychotics (Table 2).
Do antihistamines prolong QT?
Abstract. Some antihistamines, such as mizolastine and ebastine, can prolong the QT interval and provoke severe cardiac arrhythmias.
Does scopolamine cause QT prolongation?
Scopolamine is an antimuscarinic mediation with a similar anticholinergic side effect profile as antihistamines. However, by acting as an M1-muscarinic antagonist, it is non-sedating and does not prolong the QTc.
Does dexamethasone cause QT prolongation?
Treatment with high-dose dexamethasone was repeatedly associated with a decrease in the QT interval that was reversible upon cessation of treatment. In this particular case, circulating cytokines due to the APL itself might be perturbing the cardiomyocyte physiology,4 and dexamethasone might mitigate these effects.
What antiemetics do not prolong QT interval?
Antiemetics That Do Not Cause QTc Prolongation Scopolamine is an antimuscarinic mediation with a similar anticholinergic side effect profile as antihistamines. However, by acting as an M1-muscarinic antagonist, it is non-sedating and does not prolong the QTc.
What antiemetic does not prolong QT?
Both ondansetron and granisetron prolong the QT interval when administered intravenously at doses over 8 mg and 10 micrograms/kg respectively. However, there have been no reports of QT prolongation following oral administration. Palonosetron and tropisetron are not associated with QT prolongation.
Does diltiazem cause QT prolongation?
Particularly, the increase in potassium outward from myocardial cells triggers shortening in action potential, QTc, and T durations. Diltiazem causes shortening in action potential and QTc prolongation due to decrease in inward calcium current in myocardial cells.
How do drugs prolong QT interval?
Pharmacokinetic: The majority of drugs that potentially prolong the QT interval are hepatically metabolized by the cytochrome isoenzymes CYP3A4, 1A2, and 2D6, with CYP3A4 responsible for the metabolism of approximately 50% of all drugs.
Why is Zofran contraindicated in prolonged QT?
The drug may increase the risk of prolongation of the QT interval of the electrocardiogram, which can lead to abnormal and potentially fatal arrhythmias, including torsade de pointes, according to an FDA press release.