How much does SOMAscan cost?
Cost: $1,800 for one SOMAscan array, though the company offers “substantial discounts for reasonable volumes, so most people don’t pay that,” Williams says.
What is SOMAscan assay?
SOMAscan is an aptamer-based proteomics assay capable of measuring 1,305 human protein analytes in serum, plasma, and other biological matrices with high sensitivity and specificity.
What is a Somamer?
SOMAmers are short, single stranded deoxyoligonucleotides. Like aptamers, they are selected in vitro from large random libraries for their ability to bind to discrete molecular targets, which can be small molecules, peptides, or proteins [4], [5].
What is a Somascan priest?
The Somascan Fathers, officially known as the Clerics Regular of Somasca (Latin: Ordo Clericorum Regularium a Somascha; abbreviated CRS), is an order of clerics regular of Pontifical Right for men. It was founded in Italy in the 16th century by Saint Jerome Emiliani and named after the motherhouse at Somasca.
What are aptamers used for?
Like monoclonal antibodies, aptamers can be used for the molecular recognition of their respective targets. Aptamers have been successfully used for pathogen recognition, cancer recognition, monitoring environmental contamination, and as stem cell markers.
What is meant by proteomics?
A proteome is the complete set of proteins expressed by an organism. The term can also be used to describe the assortment of proteins produced at a specific time in a particular cell or tissue type. The proteome is an expression of an organism’s genome.
Who is the father of CRS?
St. Jerome Emiliani
Members of the Order add the nominal letters C.R.S. after their names to indicate their membership in the congregation. There are currently about 500 Somascans serving around the world….
| Latin: Ordo Clericorum Regularium a Somascha | |
|---|---|
| Coat of arms of the Somascan Fathers | |
| Founder | St. Jerome Emiliani |
| Founded at | Venice, Italy |
What did the Theatines do?
The Theatines combined the pursuit of evangelical perfection traditional among religious orders with apostolic service generally expected of diocesan clergy. It was Caraffa who wrote the constitutions of the order.
How aptamers can be designed?
It is possible to design aptamers using simple compounds as targets as well as complex biopolymers, such as proteins. The single disadvantage is that the current level of molecular modeling makes it impossible to use cells as targets in aptamer design, which is a plus of the in vitro SELEX method.
Where are aptamers found?
Aptamers (from the Latin aptus – fit, and Greek meros – part) are oligonucleotide or peptide molecules that bind to a specific target molecule. Aptamers are usually created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.
What are proteomic biomarkers?
Proteomic biomarkers are often referred to those biomarkers discovered using technologies capable of analyzing many proteins simultaneously, such as protein microarray and mass spectrometry (MS).
What are proteomes and genomes?
What is Somascan 1?
SOMAscan 1 is a highly multiplexed, aptamer-based assay optimized for protein biomarker discovery, which is made possible by the simultaneous measurement of a broad range of protein targets.
What is the Somascan assay?
Somalogic’s SOMAscan Assay allows for the simultaneous detection of 1,300 human proteins using SOMAmer (Slow Off-rate Modified Aptamer) protein-binding reagents. The assay is capable of detecting proteins in μM to fM concentrations by using dilutions of highly specific SOMAmers that bind to their cognate proteins.
Who has generated the Somascan data?
G.F. and B.S. have generated the SOMAscan data. T.G., J.H., and S.S. have contributed samples from a multiplate longitudinal study to explore response to an Adenovirus Type 4-Influenza H5 recombinant vaccine. A.Z. and B.M.R. have contributed samples from a study of non-small-cell lung cancer and heavy smoker controls.
What is included in a typical Somascan plate design?
The typical SOMAscan plate design includes buffer wells (no sample added), quality control (QC_SOMAscan) and calibrator samples provided by SomaLogic. Quality control and calibrators are pooled samples composed of the same matrix as the biological samples being measured in the plate.
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