What is a liver sinusoid?
Sinusoids are low pressure vascular channels that receive blood from terminal branches of the hepatic artery and portal vein at the periphery of lobules and deliver it into central veins. Sinusoids are lined with endothelial cells and flanked by plates of hepatocytes.
What is histology of liver?
The liver is a mixed gland surrounded by a thin capsule of connective tissue, the Glisson capsule, dividing the parenchyma into lobules and lobuli. The histological unity of the liver is composed of the liver lobuli, with classic, portal and acini conceptions.
What is the function of bile canaliculi?
The canaliculi function to secrete and concentrate components of the bile and to transport the bile out of the interior of the hepatic parenchymal tissue to the epithelium-lined bile ducts.
What is the hepatic portal triad?
portal triad (plural portal triads) (anatomy) A distinctive component of a hepatic lobule, found running along each of the lobule’s corners, that consists of branches of the hepatic artery proper, hepatic portal vein and bile ducts, as well as other structures.
What is the relationship between hepatocytes and sinusoids?
To facilitate the exchange of a wide variety of substances between the blood and hepatocytes,the hepatocytes are directly exposed to the blood passing though the organ, by being in close contact with the liver blood sinusoids. The sinusoids carry blood from the edges of the lobule to the central vein.
Why are liver sinusoids unique?
The hepatic sinusoid is a unique, dynamic, microvascular structure that serves as the principal site of exchange between the blood and the perisinusoidal space (i.e., space of Disse). The sinusoid is the home of nonparenchymal cells, of which there are four recognized types (Figs.
What histology means?
(his-TAH-loh-jee) The study of tissues and cells under a microscope.
What does epithelial tissue do in the liver?
The epithelial cells of the liver are grouped together to form functional units referred to as liver lobules. Major functions of hepatocytes are to synthesize and secrete bile, form and store proteins, remove toxins, and store and release carbohydrates.
What are hepatocytes?
Abstract. Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins.
What do portal veins do?
The portal vein (PV) is the main vessel of the portal venous system (PVS), which drains the blood from the gastrointestinal tract, gallbladder, pancreas, and spleen to the liver.
How many portal veins are there in human body?
It is a major component of the hepatic portal system, one of only two portal venous systems in the body – with the hypophyseal portal system being the other….
| Portal vein | |
|---|---|
| Drains from | Gastrointestinal tract, spleen, pancreas |
| Source | splenic vein, superior mesenteric vein, inferior mesenteric vein, pancreatic vein |
What is lupinosis?
Lupinosis is a liver disease mainly caused by the consumption of lupin stubble colonised by the fungus Diaporthe toxica (previously called Phomopsis leptostromiformis ). It can be expressed as either a severe acute disease or as a chronic liver dysfunction syndrome.
Does lupinosis cause toxaemia?
The liver damage that occurs in lupinosis will increase the likelihood of pregnancy toxaemia in late pregnant ewes or cattle. Stock affected by lupinosis may develop secondary photosensitisation. What do you see in stock with lupinosis?
How common is lupinosis in sheep?
Lupinosis in sheep. It can be expressed as either a severe acute disease or as a chronic liver dysfunction syndrome. Acute disease is most common in livestock on sandplain or WA blue lupins following summer rains, while the chronic syndrome is commonly associated with narrow-leafed lupin stubbles or when lupin seed is fed.
What causes liver disease in blue lupins?
It can be expressed as either a severe acute disease or as a chronic liver dysfunction syndrome. Acute disease is most common in livestock on sandplain or WA blue lupins following summer rains, while the chronic syndrome is commonly associated with narrow-leafed lupin stubbles or when lupin seed is fed.
https://www.youtube.com/watch?v=eEFUVxD2Dog