What does BCL W stand for?
| BCL2L2 | |
|---|---|
| Aliases | BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2 |
| External IDs | OMIM: 601931 MGI: 108052 HomoloGene: 2989 GeneCards: BCL2L2 |
| showGene location (Human) | |
| showGene location (Mouse) |
What is the function of Bax and BCL-2?
Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, respectively.
What does Bcl XL stand for?
B-cell lymphoma-extra large
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria.
What is the function of Bcl?
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and mediate the process by which mitochondria contribute to cell death known as the intrinsic apoptosis pathway.
What do Bcl-2 family members control?
Abstract. The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.
Is BCL-2 proapoptotic and antiapoptotic?
Bcl-2 protectors protect cells against apoptosis. Bcl-2 killers (eg, Bax and Bak) are proapoptotic proteins that actively kill cells. Bcl-2 regulators (widely known as BH3-only proteins) promote cell killing by either interfering with the protectors or activating the killers.
Where is Bcl XL located?
Bcl-2 is located at the mitochondrion, endoplasmic reticulum (ER) and the nuclear envelope [14, 15]. Bcl-XL resides in the nuclear envelope, extra-nuclear membranes, including the mitochondrion but also cytosol [16, 17].
Is BCL-2 a transmembrane?
Bcl-2 protein transmembrane domains specifically homooligomerize and heterooligomerize in bacterial and mitochondrial membranes. Their interactions participate in the regulation of Bcl-2 proteins, thus modulating apoptotic activity.
Where is Bcl-2 found?
mitochondria
BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins.
How does BAX cause apoptosis?
In contrast to the Bcl-2 family members, insertion of Bax family members into the mitochondrial membrane induces the release of cytochrome C and the induction of apoptotic cell death.